Tab. Doxiva 200mg

Introduction

Doxiva is used to treat and prevent symptoms of asthma and chronic obstructive pulmonary disorder (a lung disorder in which flow of air to the lung is blocked). It helps in relaxing the muscles of the air passages, thus widening it and making it easier to breathe. Doxiva can be taken with the food in evening. But take it at the same time every day to get the most benefit. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for you. Do not miss even a single dose, if in any case, you missed a dose, take it as soon as you remember or better to skip the missed dose and continue with regular dosing. It does not work immediately or prevent the already started breathing trouble, hence always carry your medical inhaler with you for an emergency. The most common side effects of this medicine include vomiting, headache, nausea, and stomach upset. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. Generally, it is advised not to consume alcohol or do not smoke while on treatment. You must avoid high caffeinated products like coffee, tea, and dark chocolates as it enhances drug side effects. Before taking this medicine, let your doctor if you have kidney or liver disease or if you have heart-related problems. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Inform your doctor if you are pregnant or breastfeeding before starting the treatment.

Uses of Doxiva

• Chronic obstructive pulmonary disease (COPD)
• Asthma

Side effects of Doxiva

• Upset stomach
• Vomiting
• Headache
• Nausea
• Restlessness

How to use Doxiva

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Doxiva may be taken with or without food, but it is better to take it at a fixed time. Avoid Doxiva with caffeine and chocolate as well as food containing caffeine and chocolate such as tea leaves, cocoa beans.

How Doxiva works

Doxiva is a bronchodilator. It works by relaxing the muscles of the airways and widens airways. This makes breathing easier.

Indication

COPD (Chronic Obstructive Pulmonary Disease), bronchial asthma

Adult Dose

Tablet Adults: Conventional Tablet 400mg 1 to 3 times a day. Sustained release tablet: 400 mg sustained release tablet once a day. Single dose, administration in the evening reduces nocturnal, symptoms and helps to keep the patients complaint free during the day. However, in certain cases, 400 mg tablet twice daily is recommended on the basis of the clinical response and according to disease severity. Doses as high as 1200mg/day (400 mg 3 times day) may also be prescribed. Elderly: The dosage may be decreased according to medical prescription in the very elderly patients with concomitant cardiovascular, hepatic, renal and gastric disease, to 200 mg tablet b.i.d/ t.i.d. Syrup Elderly: 10 ml, 2 or 3 times daily.

Child Dose

Tablet Children >12 years: 200 mg 2 or 3 times daily. Syrup Children> 12 years: 10 ml, 2 or 3 times daily. Children<12 years: 6 mg/kg/dose twice daily. In case of unsatisfactory response it can be increased up to 9 mg/kg/dose twice daily under medical supervision.

Contraindication

This is contraindicated for individuals who have shown hypersensitivity to Doxofylline and its components. It is also contraindicated in patients with acute myocardial infarction, hypotension, and in lactating women.

Mode of Action

Doxofylline is a theophylline derivative. Similarly, its mechanism of action is related to the inhibition of phosphodiesterase activities, resulting in bronchodilating effects.

Precaution

Use with caution in patients with hypoxemia, hyperthyroidism, liver disease, renal disease, in those with history of peptic ulcer and in elderly. Frequently, patients with Congestive Heart Failure (CHF) have markedly prolonged drug serum levels following discontinuation of Doxofylline.

Side Effect

Nausea, vomiting, epigastric pain, cephalalgia, irritability, insomnia, tachycardia, extrasystole, tachypnea and occasionally, hyperglycemia and albuminuria, may occur. If a potential oral overdose is established, the patient may present with severe arrhythmias and seizure; these symptoms could be the first sign of an intoxication. Adverse reactions may cause the withdrawal from treatment; a lower dose rechallenge may start only after the advice of a physician.

Interaction

Other xanthine derivatives, ephedrine, phenytoin & other anticonvulsants, erythromycin, troleandomycin, lincomycin, clindamycin, allopurinol, cimetidine, ranitidine, propranolol, flu vaccine.