Introduction
Oxat 20 is a type of antidepressant belonging to the selective serotonin reuptake inhibitor (SSRI) group of medicines. It is widely prescribed to treat depression and anxiety-related conditions like panic disorder, obsessive-compulsive disorder, and post traumatic stress disorder (PTSD). Oxat 20 helps many people to recover from depression by improving their mood and relieving anxiety and tension. It can be taken with or without food. The dose and how often you need it will be decided by your doctor so that you get the right amount to control your symptoms. Your doctor may start you on a lower dose and increase it gradually. Do not change the dose or stop taking it without talking to your doctor, even if you feel well. Doing so may make your condition worse or you may suffer from unpleasant withdrawal symptoms (anxiety, restlessness, palpitations, dizziness, sleep disturbances, etc). To get the most benefit, take this medicine regularly at the same time each day. Your doctor may advise you to take it in the morning if you have trouble sleeping. It may take a few weeks before you start feeling better. Let your doctor know if you do not see any improvement even after 4 weeks. Some common side effects of Oxat 20 include nausea, fatigue, dry mouth, loss of appetite, increased sweating, dizziness, nervousness, tremors, insomnia (difficulty in sleeping), and constipation. Sexual side effects like decreased sexual drive, delayed ejaculation, and erectile dysfunction may also be seen. Let your doctor know straight away if you develop any sudden worsening of mood or any thoughts about harming yourself. Before taking this medicine, you should tell your doctor if you have epilepsy (seizure disorder or fits), diabetes, liver or kidney disease, heart problems, or glaucoma. These may affect your treatment. Pregnant or breastfeeding women should also consult their doctor before taking it. Some other medicines may affect the way it works, especially other antidepressants and medicines called MAO inhibitors. Please tell your doctor about all the medicines you are taking to make sure you are safe.
Uses of Oxat 20
- Depression
- Obsessive-compulsive disorder
- Post traumatic stress disorder
- Panic disorder
- Anxiety
Side effects of Oxat 20
- Delayed ejaculation
- Low sexual desire
- Nausea
- Tremor
- Confusion
- Dizziness
- Dryness in mouth
- Erectile dysfunction
- Fatigue
- Increased sweating
- Insomnia (difficulty in sleeping)
- Loss of appetite
- Nervousness
- Sleepiness
How to use Oxat 20
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Oxat 20 may be taken with or without food, but it is better to take it at a fixed time.
How Oxat 20 works
Oxat 20 is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It works by increasing the levels of serotonin, a chemical messenger in the brain. This improves mood and physical symptoms of depression and also relieves symptoms of post traumatic stress disorder, panic disorder, anxiety and obsessive-compulsive disorder.
- It can take 2-3 weeks for Pexep CR 12.5 Tablet to start working.
- Do not stop treatment suddenly as this may cause upset stomach, flu-like withdrawal symptoms and sleep disturbance.
- If your doctor asks you to stop Pexep CR 12.5 Tablet, you should reduce the dose slowly over 4 weeks.
- Avoid consuming alcohol when taking Pexep CR 12.5 Tablet, as it may cause excessive drowsiness and calmness.
- The addiction/dependence potential of Pexep CR 12.5 Tablet is very less.
Indication
Depression, Anxiety, Panic disorder, Obsessive-compulsive disorder, Posttraumatic stress disorder, Social anxiety disorder, Premenstrual dysmorphic disorder
Administration
May be taken with or without food. May be taken w/ meals to minimise GI upset.
Adult Dose
Oral Depression, Anxiety, Posttraumatic stress disorder Adult: 20 mg daily, increase gradually, if necessary, by 10-mg increments wkly; max: 50 mg/day. Obsessive compulsive disorder, Social anxiety disorder Adult: Initially, 20 mg daily, increase wkly in 10-mg increments. Maintenance: 40-60 mg daily. Panic disorder with or without agoraphobia Adult: Initially, 10 mg daily, increase wkly in 10-mg increments according to clinical response. Maintenance: 40-60 mg daily. Elderly: Initially, 10 mg daily, increase if needed by 10 mg/day at 1 wk intervals; max: 40 mg daily. Hepatic impairment: Severe: 10 mg daily, increase to a max of 40 mg daily as necessary.
Child Dose
Safety and efficacy not established
Renal Dose
Renal impairment: Severe: 10 mg daily, increase to a max of 40 mg daily as necessary.
Contraindication
Use with or within 14 days of MAOIs; concurrent use with thioridazine or pimozide.
Mode of Action
Paroxetine selectively inhibits the reuptake of serotonin. It has limited direct action at other neurotransmitter sites including muscarinic receptors.
Precaution
Epilepsy, glaucoma, history of mania, cardiac disease, DM, history of bleeding disorders, on drugs with increased risk of bleeding; renal and hepatic impairment; patients receiving electroconvulsive therapy; achlorhydria or high gastric pH (reduced absorption of oral suspension). Pregnancy and lactation. The risk of suicidal behaviour may be higher in young adults, closely monitor. May impair ability to drive or perform tasks. Avoid abrupt withdrawal. Lactation Excreted in breast milk; use caution (AAP states effect on nursing infants is unknown but may be of concern)
Side Effect
>10% (Based on 40 mg Dose) Nausea (15-24%),Insomnia (11-24%),Dry mouth (9-18%),Headache (17%),Asthenia (10-15%),Constipation (10-15%),Diarrhea (9-12%),Dizziness (6-14%),Ejaculation disorder (10-15%),Tremor (4-11%), 1-10% (Based on 40 mg Dose) Anxiety (5-10%),Blurred vision (5-10%),Decreased appetite (5-10%),Impotence (2-9%),Nervousness (2-5%),Paresthesia (2-5%),Hypomania (0.3 to 2.2%) Frequency Not Defined (Based on 40 mg Dose) Hypertension,Tachycardia,Emotional lability,Pruritus,Weight gain,Arthralgia,Tinnitus.Vertigo.Angle clossure glaucoma Serious Depression exacerbation,Mania (rare),Serotonin syndrome,Suicidal thoughts (rare),Suicide (rare),Seizure (rare),Toxic epidermal necrolysis,Hyponatremia (rare),Bleeding, abnormal (rare).Acute hepatitis (rare).Stevens-Johnson Syndrome
Interaction
Levels/effects inhibited by cyproheptadine, phenytoin. Levels/effects increased by carbamazepine, cimetidine, CYP2D6 inhibitors (e.g. chlorpromazine, delavirdine, fluoxetine, miconazole, pergolide, quinidine, quinine, ritonavir, ropinirole). Increases levels/effects of atomoxetine, carvedilol, clozapine, CYP2B6 substrates (e.g. bupropion, promethazine, propofol, selegiline, sertraline), CYP2D6 substrates (e.g. amphetamines, selected beta-blockers, dextromethorphan, fluoxetine, lidocaine, mirtazapine, nefazodone, risperidone, ritonavir, thioridazine, TCAs, venlafaxine), duloxetine, galantamine, mexilitine, pimozide, procyclidine, propafenone. Decreases levels/effects of CYP2D6 prodrug substrates (e.g. codeine, hydrocodone, oxycodone, tramadol). Inhibits the metabolism of dextromethorphan, haloperidol, thioridazine. Enhances bradycardic effect of beta-blockers. Enhances toxic effects of other CNS depressants. Increased risk of serotonin syndrome with amphetamines, SSRIs, meperidine, nefazodone, trazodone, serotonin agonists, sibutramine, sympathomimetics, tramadol, venlafaxine. Increases risk of bleeding with NSAIDs, aspirin, warfarin, or other drugs affecting coagulation. Increases sensitivity to amphetamines. Neurotoxicity with lithium. Additive hyponatraemia with loop diuretics. Mania or hypertension with selegiline. Potentially Fatal: Fatal reactions with nonselective MAOI.
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