HPV (Human Papiloma Virus) Reagent – Jaj International

Human papillomavirus (HPV) is a group of more than 200 related viruses, of which more than 40 are spread through direct sexual contact. Several HPV types cause genital warts, and about a dozen HPV types can cause certain cancer types – cervical, anal, oropharyngeal, penile, vulvar and vaginal. The HPV virus is small and non-enveloped, with a single, circular dsDNA contained within a T=7 icosahedral capsid composed of 72 pentamers.

The HPV genome is composed of six early (E1,E2, E3, E4, E6 and E7) and two late (L1 and L2) proteins. The late proteins, translated in the upper layers of the host epithelium, serve as structural proteins that encapsulate the amplified viral genomes. FDA-approved vaccines that have shown to produce protective antibodies include Gardasil (types 6,11,16,18) & Gardasil 9 (with add’l types 31,33,45,52 & 58) and Cervarix (types 16,18), which are composed of recombinant L1 protein as virus-like particles (VLP). PRINCIPLE OF THE TEST The Human Anti-HPV IgG ELISA