Ferritin Reagent – Jaj International

Ferritin is a high-molecular iron storage protein (MW approx. 450,000) which can incorporate varying amounts of iron in the form of iron. The Iron represents approximately 25% of the total molecular weight. Ferritin can mainly be found in the cytoplasm of the reticuloendothelial cells, in liver cells and to a small extent in the precursors of the red cells in the bone marrow. It stores Iron in a biologically modifiable form. Thus, it gives a measure of the amount of iron available for hemoglobin synthesis

The determination of serum ferritin has its significance in the diagnosis and monitoring of Iron deficiency. Reduced ferritin serum levels Indicate Iron deficiency: iron overload or idiopathic hemochromatosis are associated with elevated ferritin serum concentrations. Elevated ferritin levels have also been found in a variety of malignancies, especially in Hodgkin- or Non-Hodgkin lymphoma, acute or chronic leukemia as well as in breast or bronchial carcinoma