Loxodol (8mg)

Concomitant administration of Lomoxicam and combination with Vitamin K antagonists like warfarin increases the risk of bleeding. Combination with Cyclosporin can lead to reduced kidney function and to acute kidney injury in rare cases. Lomoxicam can also increase the adverse effects of lithium, methotrexate and digoxin and its derivatives. The effect of diuretics, ACE inhibitors and angiotensin II receptor antagonists can be reduced in patients with heart failure.

Hypersensitivity to Lomoxicam or to any of the excipients, peptic ulcer, severe hepatic impairment, severe renal impairment (Serum creatinine > 700 pmol/l) and Thrombocytopenia and the third trimester of pregnancy.

The most commonly observed adverse events of NSAIDs are gastrointestinal in nature. Peptic ulcers, perforation or Gl bleeding, sometimes fatal, particularly in the elderly, may occur. Nausea, vomiting, diarrhea, flatulence, constipation, dyspepsia, abdominal pain, melaena, hematemesis, ulcerative stomatitis, exacerbation of colitis and Crohn’s disease have been reported by following administration of NSAIDs.

Lomoxicam is contraindicated on the third trimester of pregnancy and should not be used during pregnancy in the first and second trimesters and delivery, as no clinical data on exposed pregnancies are available. There are no data on the excretion of Lomoxicam in human breast milk. Lomoxicam is excreted in milk of lactating rats in relatively high concentrations. Therefore lomoxicam should not be used in breastfeeding women.

Lomoxicam should be taken carefully when someone has impaired kidney function, someone has a history of high blood pressure or heart failure, someone suffers from ulcerative colitis or Crohn’s diseases, someone has a history of bleeding tendency, someone has a history of asthma & someone suffers from SLE (Systemic Lupus Erythematosus) a rare immunological disease and women who are taking treatment for infertility.

At this time, there is no experience of overdose to permit definition of the consequence of an overdose, or to suggest specific managements. However, it can be expected that after an overdose with Lomoxicam, the following symptoms can be seen: Nausea, vomiting, cerebral symptoms (dizziness, disturbances in vision). In the case of a real or suspected overdose, the medicinal product should be withdrawn. Due to its short half-life, Lomoxicam is rapidly excreted. Lomoxicam is not dialyzable. No specific antidote is known to date. The usual emergency measures including gastric lavage should be considered.

Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Keep out of the reach of children. Store below 30°C. Protect from light and moisture. Keep all medicines out of the reach of children.