Introduction
Ameloss 5 is used to treat mild to moderate dementia in Alzheimer’s disease, a progressive illness which gradually affects memory and thinking. It does not cure this illnesses but may help improve memory, awareness and other symptoms. Your doctor will explain how to take Ameloss 5 and give you the one most suitable for you. Follow the instructions carefully to get the most benefit. The dose may change from time to time to suit your individual needs. You may take it with food, preferably at night before going to bed. It can take up to few weeks for symptoms to improve so keep taking your medicine regularly. You should not stop taking this medicine without consulting your doctor. Some common side effects of this medicine include diarrhea, nausea, and vomiting. Drink plenty of fluids to keep yourself hydrated. Some people may experience insomnia (sleeplessness), dizziness and hallucinations. You may have side effects more often when you start your treatment or when your dose is increased. Usually, the side effects will slowly go away as your body gets used to the Ameloss 5. If they are severe or will not go away, you should contact your doctor. Before using Ameloss 5, you should tell your doctor if you have ever had heart problems, stomach ulcer, epilepsy or asthma. It may also affect, or be affected by, some other drugs you are using so let your doctor know what these are to be safe. During pregnancy this medicine should only be taken if it is advised.
Uses of Ameloss 5
- Alzheimer's disease
Side effects of Ameloss 5
- Nausea
- Vomiting
- Diarrhea
How to use Ameloss 5
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Ameloss 5 may be taken with or without food, but it is better to take it at a fixed time.
How Ameloss 5 works
Memory loss in Alzheimer’s disease occurs due to disturbances of signal transmission in the brain. Ameloss 5 is a cholinesterase inhibitor. It works by increasing the levels of a chemical messenger (acetylcholine) involved in transmmission of nerve signals. This improves memory and thinking.
What if you forget to take Ameloss 5?
If you miss a dose of Ameloss 5, skip it and continue with your normal schedule. Do not double the dose.
- You have been prescribed Ameloss 5 to slow down the progression of Alzheimer’s disease.
- It does not cure Alzheimer’s disease but may help improve brain function and ability to do daily activities.
- Take it with or without food, preferably at night before going to bed.
- It may cause diarrhea, nausea, and vomiting. Drink plenty of fluids to keep yourself hydrated while taking Ameloss 5.
- Monitor your body weight regularly as both Ameloss 5 and Alzheimer’s disease can cause weight loss.
- Do not drive or do anything that requires mental focus until you know how Ameloss 5 affects you.
- Be cautious while taking this medicine if you suffer from peptic ulcer as it may cause vomiting, stomach bleeding, stomach pain, or discomfort.
- Inform your doctor if you develop muscle tremors, especially if you have Parkinson’s disease.
- Inform your doctor if you experience seizures or convulsions while taking this medicine.
Indication
Mild to moderately, severe dementia in Alzheimer’s disease.
Administration
May be taken with or without food.
Adult Dose
Oral Mild to moderately severe dementia in Alzheimer’s disease Adult: Initially, 5 mg daily at bedtime, increase if necessary up to 10 mg once daily at bedtime after 4-6 wk. Elderly: Initially, 5 mg daily at bedtime, increase if necessary up to 10 mg once daily at bedtime after 4-6 wk. Hepatic impairment: A similar dose schedule can be followed for patients with mild to moderate hepatic impairment as clearance of donepezil hydrochloride is not affected by these conditions.
Renal Dose
Renal impairment: A similar dose schedule can be followed for patients with renal impairment as clearance of donepezil hydrochloride is not affected by these conditions.
Contraindication
Donepezil is contraindicated in patients with known hypersensitivity to donepezil hydrochloride or to piperidine derivatives.
Mode of Action
Donepezil reversibly and noncompetitively inhibits centrally-active acetylcholinesterase. It is used for the symptomatic treatment of Alzheimer’s disease.
Precaution
Caution when used in patients with sick sinus syndrome or cardiac conduction abnormalities. May increase secretion of gastric acid; caution when used in patients at risk of ulcer disease. Patients with COPD, asthma, history of epilepsy, bladder obstruction, prostatic hypertrophy. May cause dose-related diarrhoea, nausea and/or vomiting which usually resolves after 1-3 wk. Safety and efficacy have not been established in children. Pregnancy, lactation.
Side Effect
Nausea, vomiting, anorexia, wt loss, diarrhoea, insomnia, fatigue, muscle cramps; headache and dizziness; syncope, bradycardia; convulsions; increased liver transaminases; sinoatrial and atrioventricular block; hallucinations, agitation and aggressive behavior; minor increases in plasma creatine kinase; potentially bladder outflow obstruction.
Pregnancy Category Note
Pregnancy There are no adequate data on developmental risks associated with use in pregnant women Lactation There are no data on presence of donepezil or metabolites in human milk, effects on breastfed infant, or on milk production; developmental and health benefits of breastfeeding should be considered along with mother’s clinical need for therapy and any potential adverse effects on breastfed infant from drug or from underlying maternal condition
Interaction
May increase the neurotoxic effect of antipsychotics. Concurrent use with systemic corticosteroids may increase the adverse effects of donepezil. May increase the neuromuscular-blocking effect of succinylcholine. May increase the adverse effects of cholinergic agonists. May increase the bradycardic effect of beta-blockers.
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